TABLE 1

Activity Yield, Molar Activity, Partition Coefficient, and Binding Affinity of ¹⁸F-Labeled PSMA Radiotracers

Tracer	Activity yield^* (%, isolated)	Molar activity^† (GBq/μmol)	LogD_7.4 (n = 3)	K_i (nM) (n = 3)
¹⁸F-DCFPyL	12 ± 3 (n = 7)	118 ± 37 (n = 7)	−3.12 ± 0.22	2.0 ± 0.8
¹⁸F-1	7 ± 4 (n = 4)	70 ± 19 (n = 4)	−3.43 ± 0.35	14.4 ± 2.7
¹⁸F-2	4 ± 2 (n = 3)	89 ± 26 (n = 3)	−4.26 ± 0.04	11.8 ± 0.9
¹⁸F-3	5 ± 1 (n = 3)	56 ± 15 (n = 3)	−4.01 ± 0.14	25.9 ± 5.7
¹⁸F-4	16 ± 2 (n = 3)	148 ± 89 (n = 3)	−3.34 ± 0.02	27.6 ± 3.8
¹⁸F-5	13 ± 10 (n = 2)	137 ± 22 (n = 2)	−3.52 ± 0.21	1.14 ± 0.26
¹⁸F-6	15 ± 2 (n = 6)	278 ± 73 (n = 6)	−2.28 ± 0.01	1.90 ± 0.68
¹⁸F-7	10 ± 5 (n = 3)	92 ± 22 (n = 2)	−3.24 ± 0.03	16.5 ± 5.5
¹⁸F-8	7 ± 6 (n = 3)	211 ± 48 (n = 3)	−3.58 ± 0.36	0.22 ± 0.01

↵* Activity yields are reported at end of synthesis (1 h for DCFPyL, 40 min for 1–8) (with no correction for decay).
↵† Molar activities are reported at time of quality control injection, shortly after end of synthesis.