TABLE 4

Calculated Individual Doses Using Specific Activity, Volume Administered, and Assumption of 7 × 10⁵ Antigen/Cell

	200-μm sphere		300-μm sphere
Single-cell dose (Gy)	10-Gy^* isodepth (μm)	Volume (%) > 10 Gy^*	10-Gy^* isodepth (μm)	Volume (%) > 10 Gy^*
4.5	88	99.8	72	86
7.0	88	99.8	73	86
5.5	85	99.7	72	86
9.9	82	99.4	72	86
6.0	100	100.0	85	92
6.9	100	100.0	85	92
9.2	100	100.0	98	96
6.0	100	100.0	95	95
4.7	100	100.0	88	93
24.6	100	100.0	101	97
45.1	100	100.0	97	96
52.2	100	100.0	97	96

↵* Dose level that is considered sufficient for small-tumor eradication, presuming RBE of 5.