TABLE 1

IC50 and Ki Values for JNJ-64413739 (Mean ± SD)

AssayJNJ-64413739
IC50 P2X7 human (nM)1.0 ± 0.2
IC50 P2X7 rat (nM)2.0 ± 0.6
Ki P2X7 human (nM)15.9 ± 2.0
Ki P2X7 rat (nM)2.7 ± 1.1

  • IC50 = half-maximal inhibitory concentration; Ki = binding affinity.