TABLE 2

Radiation Dosimetry and Clearance Kinetics Parameters for ²²⁵Ac-DOTA-MC1RL in Non–Tumor-Bearing BALB/c Mice

Parameter	Blood	Brain	Heart	Intestine	Kidney	Liver	Lung	Muscle	Skin	Spleen
²²⁵Ac
Initial activity/organ (kBq)	ND	0.0065	0.0161	1.9113	0.7647	7.6597	0.0512	0.0044	0.0483	0.0426
Effective decay rate constant (h⁻¹)	ND	0.0070	0.0030	0.0060	0.0060	0.0040	0.0030	0.0030	0.0050	0.0030
Effective decay half-life (d)	ND	4.1259	9.6270	4.8135	4.8135	7.2203	9.6270	9.6270	5.7762	9.6270
Accumulated activity/organ (kBq × h)	ND	0.7621	3.8089	260.3419	104.1599	1484.6038	12.1242	1.0529	7.7927	10.0784
Absorbed dose/injected activity (Gy/kBq)	ND	0.0002	0.0023	0.0102	0.0300	0.1485	0.0042	0.0004	0.0024	0.0092
²²¹Fr
Initial activity/organ (kBq)	0.0153	0.0222	0.0349	1.9927	1.3795	8.4464	0.0723	0.0211	0.0705	0.0647
Effective decay rate constant (h⁻¹)	0.0010	0.0030	0.0050	0.0070	0.0080	0.0040	0.0020	0.0030	0.0040	0.0040
Effective decay half-life (d)	28.8811	9.6270	5.7762	4.1259	3.6101	7.2203	14.4406	9.6270	7.2203	7.2203
Accumulated activity/organ (kBq × h)	5.6907	5.2622	5.6292	232.2869	139.2517	1637.0734	21.2642	4.9899	13.6614	12.5317
Absorbed dose/injected activity (Gy/kBq)	0.0022	0.0013	0.0037	0.0098	0.0434	0.1770	0.0080	0.0018	0.0045	0.0124
²¹⁷At
Initial activity/organ (kBq)	0.0153	0.0222	0.0349	1.9927	1.3795	8.4464	0.0723	0.0211	0.0705	0.0647
Effective decay rate constant (h⁻¹)	0.0010	0.0030	0.0050	0.0070	0.0080	0.0040	0.0020	0.0030	0.0040	0.0040
Effective decay half-life (d)	28.8811	9.6270	5.7762	4.1259	3.6101	7.2203	14.4406	9.6270	7.2203	7.2203
Accumulated activity/organ (kBq × h)	5.6907	5.2622	5.6292	232.2869	139.2517	1637.0734	21.2642	4.9899	13.6614	12.5317
Absorbed dose/injected activity (Gy/kBq)	0.0025	0.0014	0.0042	0.0110	0.0486	0.1983	0.0090	0.0021	0.0050	0.0139
²¹³Bi
Initial activity/organ (kBq)	0.0236	0.0195	0.0309	1.8886	1.0318	6.5122	0.0717	0.0152	0.0627	0.0511
Effective decay rate constant (h⁻¹)	0.0010	0.0010	0.0020	0.0050	0.0040	0.0040	0.0020	0.0020	0.0030	0.0030
Effective decay half-life (d)	28.8811	28.881	14.4406	5.7762	7.2203	7.2203	14.4406	14.4406	9.6270	9.6270
Accumulated activity/organ (kBq × h)	8.7917	7.2573	9.0914	304.6111	199.9839	1262.1858	21.0948	4.4603	14.8376	12.1064
Absorbed dose/injected activity (Gy/kBq)	0.0001	0.0000	0.0001	0.0002	0.0012	0.0025	0.0001	0.0000	0.0001	0.0002
²¹³Po
Initial activity/organ (kBq)	0.0236	0.0195	0.0309	1.8886	1.0318	6.5122	0.0717	0.0152	0.0627	0.0511
Effective decay rate constant (h⁻¹)	0.0010	0.0010	0.0020	0.0050	0.0040	0.0040	0.0020	0.0020	0.0030	0.0030
Effective decay half-life (d)	28.8811	28.881	14.4406	5.7762	7.2203	7.2203	14.4406	14.4406	9.6270	9.6270
Accumulated activity/organ (kBq × h)	8.7917	7.2573	9.0914	304.6111	199.9839	1262.1858	21.0948	4.4603	14.8376	12.1064
Absorbed dose/injected activity (Gy/kBq)	0.0044	0.0023	0.0079	0.0168	0.0811	0.1778	0.0103	0.0021	0.0063	0.0156
Total absorbed dose/injected activity (Gy/kBq)	0.0092	0.0053	0.0183	0.0481	0.2042	0.7042	0.0317	0.0064	0.0182	0.0512

ND = not detected.