TABLE 3

Healthy Tissue Uptake of PCa PET Tracers

Tracer	SUV_max	SUV_mean	COV
⁶⁸Ga-PSMA
Blood pool	1.33 (0.81–1.85)	1.08 (0.64–1.52)	19.9%
Lung apically	1.05 (0.44–1.66)	0.56 (0.2–0.91)	29.8%^*
Muscle	0.94 (0.37–1.51)	0.50 (0.14–0.86)	30.8%^*
Liver	6.41 (2.41–10.4)	4.78 (1.61–7.96)	31.8%^*
Thoracic vertebra	1.25 (0.44–2.05)	0.69 (0.25–1.13)	33.0%^*
Lumbar vertebra	1.24 (0.39–2.09)	0.67 (0.16–1.17)	35.0%^*
Lung basally	1.36 (0.42–2.3)	0.73 (0.27–1.19)	35.2%^*
¹⁸F-DCFPyL
Blood pool	1.12 (0.81–1.44)	1.01 (0.74–1.27)	14.4%
Liver	6.84 (3.93–9.75)	5.92 (3.31–8.53)	21.7%
Thoracic vertebra	1.06 (0.49–1.62)	0.75 (0.33–1.16)	27.2%^*
Lung apically	0.64 (0.28–1)	0.44 (0.19–0.68)	28.5%^*
Lung basally	0.78 (0.31–1.25)	0.50 (0.25–0.76)	31.0%^*
Lumbar vertebra	1.07 (0.39–1.75)	0.77 (0.28–1.26)	32.3%^*
Muscle	0.79 (0.26–1.33)	0.55 (0.14–0.97)	34.5%^*
¹⁸F-FCH
Liver	10.84 (7.27–14.42)	9.17 (6.11–12.23)	16.8%
Thoracic vertebra	3.68 (2.22–5.13)	2.78 (1.64–3.93)	20.2%
Blood pool	0.75 (0.42–1.08)	0.63 (0.34–0.91)	22.5%
Lumbar vertebra	3.13 (1.65–4.62)	2.33 (1.13–3.53)	24.2%
Lung apically	1.03 (0.46–1.6)	0.64 (0.23–1.05)	28.2%^*
Muscle	1.72 (0.66–2.78)	1.25 (0.33–2.16)	31.4%^*
Lung basally	1.48 (0.56–2.4)	0.95 (0.4–1.5)	31.6%^*
¹⁸F-FDHT
Liver	5.12 (3.65–7.08)	4.10 (2.83–6.06)	14.6%
Blood pool	5.24 (3.06–7.2)	4.71 (2.45–6.67)	21.2%
Thoracic vertebra	1.95 (1.12–3.91)	1.36 (0.86–3.32)	21.6%
Muscle	1.14 (0.62–3.1)	0.76 (0.47–2.72)	23.1%
Lumbar vertebra	2.18 (1.17–4.14)	1.60 (0.89–3.56)	23.6%
Lung basally	1.61 (0.71–3.57)	1.00 (0.51–2.96)	28.6%^*
Lung apically	1.36 (0.31–3.32)	0.90 (0.26–2.86)	39.3%^*

↵* Significantly different from the least variable tissue.
Data are average SUV and 95% population reference ranges (in parentheses), in order of uptake variability (COV, based on SUV_max). Supplemental Table 2 provides complete results.