Regional Binding Parameters for 11C-LSN3172176 at Baseline and After Preblocking with Scopolamine and AZD6088
| Preblocking VT (MA1, t* = 30) | BPND | |||||
| AZD6088 | ||||||
| Brain region | Baseline VT (n = 4) | Scopolamine, 50 μg/kg (n = 2) | 0.67 mg/kg (n = 1) | 2 mg/kg (n = 1) | SRTM, baseline (n = 4) | MA1 (t* = 30), baseline (n = 4) |
| Amygdala | 33.8 (4.0) | 7.2 (1.3) | 13.49 | 8.40 | 2.54 (0.3) | 3.23 (0.54) |
| Brain stem | 7.7 (0.9) | 7.3 (1.1) | 7.28 | 5.99 | 0.08 (0.02) | −0.04 (0.07) |
| Caudate | 62.6 (10) | 8.0 (1.0) | 24.29 | 13.83 | 5.46 (0.62) | 6.77 (0.76) |
| Cerebellum | 8.1 (1.3) | 7.0 (1.2) | 7.37 | 6.41 | – | – |
| Cingulate | 53.8 (7.1) | 8.1 (0.8) | 19.55 | 12.12 | 4.45 (0.2) | 5.68 (0.26) |
| Frontal cortex | 50.7 (5) | 7.5 (0.5) | 17.92 | 11.25 | 4.03 (0.2) | 5.33 (0.37) |
| Globus pallidus | 27.4 (2.6) | 7.8 (1.3) | 15.59 | 9.14 | 2.09 (0.14) | 2.42 (0.21) |
| Hippocampus | 43.5 (6.0) | 8.0 (1.3) | 18.16 | 10.19 | 3.37 (0.31) | 4.41 (0.51) |
| Insula | 56.6 (7.9) | 7.8 (1.1) | 18.50 | 11.65 | 4.56 (0.31) | 6.02 (0.38) |
| Nucleus accumbens | 75.6 (4.7) | 8.2 (1.3) | 30.33 | 12.82 | 6.24 (0.44) | 8.48 (0.85) |
| Occipital cortex | 40.4 (5.2) | 7.1 (0.9) | 18.11 | 11.54 | 3.08 (0.13) | 4.02 (0.18) |
| Pons | 8.5 (1.1) | 8.1 (0.9) | 8.26 | 7.06 | 0.17 (0.04) | 0.05 (0.06) |
| Putamen | 68.6 (10.7) | 8.8 (2.0) | 26.67 | 15.85 | 6.04 (0.59) | 7.50 (0.6) |
| Substantia nigra | 10.3 (1.8) | 7.7 (1.3) | 8.55 | 10.57 | 0.37 (0.05) | 0.27 (0.07) |
| Temporal cortex | 48.5 (6.9) | 6.8 (0.7) | 17.76 | 11.00 | 3.77 (0.18) | 5.01 (0.22) |
| Thalamus | 13.6 (1.7) | 7.0 (1.1) | 10.75 | 7.11 | 0.75 (0.12) | 0.69 (0.14) |
Values in parentheses are SDs.