TABLE 3
Target Occupancy of JNJ-54175446 in Nonhuman Primates
Dose (mg/kg)
AUC (ng/mL × min)
Receptor occupancy (%)
Monkey
5.3
132470
51.7
2
2.5
46991
60.4
1
2.5
42353
55.1
2
0.4
5764
52.1
2
0.1
2102
17.6
1
AUC = area under the curve.