Comparison of Binding Parameters Derived from MA1 Between Baseline Scans of 11C-EKAP and 11C-GR103545 in Same Monkeys
| Parameter | Cingulate cortex | Globus pallidus | Insula | Caudate nucleus | Frontal cortex | Putamen | Temporal cortex | Thalamus | Cerebellum |
| VT (mL⋅cm−3) | |||||||||
| 11C-EKAP (n = 3) | 32.7 ± 3.7 | 34.3 ± 1.2 | 29.0 ± 2.7 | 22.9 ± 1.5 | 20.4 ± 2.6 | 19.8 ± 1.7 | 19.7 ± 1.1 | 14.5 ± 1.4 | 12.1 ± 0.9 |
| 11C-GR103545 (n = 2) | 67.2 ± 19.2 | 46.6 ± 10.4 | 46.8 ± 10.4 | 37.8 ± 4.9 | 32.0 ± 4.1 | 33.5 ± 7.0 | 29.9 ± 3.5 | 18.6 ± 3.2 | 15.4 ± 2.0 |
| BPND | |||||||||
| 11C-EKAP (n = 3) | 1.70 ± 0.20 | 1.84 ± 0.24 | 1.40 ± 0.15 | 0.89 ± 0.07 | 0.68 ± 0.12 | 0.64 ± 0.02 | 0.63 ± 0.08 | 0.20 ± 0.03 | — |
| 11C-GR103545 (n = 2) | 3.33 ± 0.70 | 2.01 ± 0.29 | 2.03 ± 0.29 | 1.46 ± 0.01 | 1.08 ± 0.00 | 1.17 ± 0.18 | 0.94 ± 0.02 | 0.21 ± 0.06 | — |