Parameter | Cingulate cortex | Globus pallidus | Insula | Caudate nucleus | Frontal cortex | Putamen | Temporal cortex | Thalamus | Cerebellum |
Baseline (n = 5) | 36.1 ± 7.7 | 36.5 ± 4.8 | 32.4 ± 6.7 | 24.6 ± 3.8 | 23.7 ± 8.2 | 22.6 ± 5.0 | 21.7 ± 4.7 | 16.8 ± 5.3 | 13.1 ± 2.2 |
11C-14 baseline | 17.9 | 15.1 | 17.6 | 15.9 | 14.9 | 16.3 | 15.2 | 16.1 | 14.7 |
Naloxone blocking (1 mg/kg, n = 2) | 12.0 ± 0.2 | 11.8 ± 0.2 | 11.9 ± 0.3 | 10.6 ± 0.4 | 10.2 ± 0.4 | 10.8 ± 0.1 | 9.6 ± 0.5 | 9.4 ± 0.1 | 8.6 ± 0.6 |
LY2795050 blocking (0.2 mg/kg) | 13.7 | 11.9 | 12.6 | 11.7 | 11.1 | 12.0 | 10.5 | 10.9 | 10.0 |
LY2456302 blocking (0.05 mg/kg) | 21.5 | 16.7 | 18.6 | 15.6 | 15.8 | 15.4 | 14.5 | 14.7 | 12.7 |
LY2456302 blocking (0.3 mg/kg) | 15.7 | 14.7 | 15.5 | 14.3 | 14.7 | 16.4 | 12.4 | 13.6 | 12.9 |