TABLE 5

Baseline Toxicity Grade Before ¹⁷⁷Lu-PRLT and Worst Toxicity Grade Achieved After ¹⁷⁷Lu-PRLT

	T-pretreated (n = 83)		T-naïve (n = 84)
Organ system	Before ¹⁷⁷Lu-PRLT	After ¹⁷⁷Lu-PRLT	Before ¹⁷⁷Lu-PRLT	After ¹⁷⁷Lu-PRLT
Hematologic toxicity
Anemia
All grades	77 (93%)	80 (96%)	65 (77%)	82 (98%)
Grade 3 or 4	3 (4%)	7 (8%)	0 (0%)	1 (1%)
Leukocytopenia
All grades	10 (12%)	25 (30%)	8 (10%)	22 (26%)
Grade 3 or 4	0 (0%)	2 (2%)	0 (0%)	0 (0%)
Thrombocytopenia
All grades	11 (13%)	30 (36%)	10 (12%)	22 (26%)
Grade 3 or 4	1 (1%)	3 (4%)	0 (0%)	1 (1%)
Renal toxicity^*
Creatinine
All grades	16 (19%)	21 (25%)	9 (11%)	20 (24%)
Grade 3 or 4	0 (0%)	0 (0%)	0 (0%)	0 (0%)
eGFR
All grades	17 (20%)	22 (27%)	9 (11%)	20 (24%)
Grade 3 or 4	2 (2%)	2 (2%)	1 (1%)	2 (2%)
Hepatic toxicity^*
Bilirubin
All grades	1 (1%)	4 (5%)	2 (2%)	3 (4%)
Grade 3 or 4	0 (0%)	0 (0%)	0 (0%)	0 (0%)
AST
All grades	19 (23%)	33 (40%)	8 (10%)	15 (18%)
Grade 3 or 4	0 (0%)	0 (0%)	0 (0%)	0 (0%)
ALT
All grades	2 (2%)	10 (12%)	2 (2%)	4 (5%)
Grade 3 or 4	0 (0%)	0 (0%)	0 (0%)	0 (0%)
GGT^†
All grades	24 (29%)	31 (38%)	13 (16%)	20 (24%)
Grade 3 or 4	4 (5%)	10 (12%)	0 (0%)	3 (4%)
ALP
All grades	41 (49%)	50 (60%)	22 (27%)	30 (36%)
Grade 3 or 4	5 (6%)	9 (11%)	4 (5%)	8 (10%)

↵* Baseline data available for 83 patients in the T-naïve group.
↵† Data available for 82 patients in the T-pretreated group.
AST = aspartate aminotransferase; ALT = alanine aminotransferase; GGT = γ-glutamyl transferase.