TABLE 1

Baseline Characteristics at Time of First ¹⁷⁷Lu-PRLT and Gleason Score/Disease Stage at Initial Diagnosis

Characteristic	T-pretreated (n = 83)	T-naïve (n = 84)	P
Age (y)	69.3 ± 8.7	70.8 ± 7.8	0.249
Karnofsky performance status			0.003
<70	16 (19%)	6 (7%)
70	13 (16%)	7 (8%)
80	24 (29%)	24 (29%)
90	28 (34%)	33 (39%)
100	2 (2%)	14 (17%)
Metastatic disease extent
Bone metastases	75 (90%)	66 (79%)	0.036
Nodal metastases	68 (82%)	68 (81%)	0.871
Visceral metastases (liver or lung)	20 (24%)	16 (19%)	0.428
Additional prior therapy
Abiraterone or enzalutamide	63 (76%)	32 (38%)	<0.001
Nontaxane chemotherapy	9 (11%)	0 (0%)	NA
²²³Ra	12 (14%)	2 (2%)	0.005
External beam radiotherapy to bone	30 (36%)	25 (30%)	0.380
Time between initial diagnosis and first ¹⁷⁷Lu-PRLT (mo)	68.8 (34.3–125.7)	72.3 (32.5–132.8)	0.813
PSA (ng/mL)	196.3 (34.1–766.1)	33.6 (4.9–106.4)	<0.001
Hematologic results
Hemoglobin (mmol/L)	6.9 (5.9–7.9)	8.0 (7.2–8.5)	<0.001
Red blood cell count (10 ^ 6/μL)	4.0 (3.5–4.3)	4.2 (3.9–4.5)	0.002
White blood cell count (10 ^ 3/μL)	6.6 (5.0–8.1)	6.2 (5.0–7.2)	0.129
Platelet count (10 ^ 3/μL)	207 (181–265)	216 (173–259)	0.794
Renal function tests^*
Creatinine (μmol/L)	77.5 (67.8–92.0)	77.7 (68.2–92.6)	0.753
Urea (mmol/L)	7.0 (5.4–8.5)	6.3 (5.3–7.4)	0.048
eGFR (mL/min)	86.1 (70.5–100.6)	86.2 (70.0–97.8)	0.848
Liver function tests^*
Bilirubin (μmol/L)	5 (4–7)	6 (5–8)	0.016
AST (U/L)	26 (20–50)	23 (19–31)	0.044
ALT (U/L)	16 (12–24)	17 (12–24)	0.600
GGT (U/L)^†	32 (22–80)	22 (17–48)	0.004
ALP (U/L)	128 (69–282)	84 (60–150)	0.007
Gleason score at initial diagnosis			0.062
≤7	19 (23%)	33 (39%)
≥8	46 (55%)	41 (49%)
Unknown	18 (22%)	10 (12%)
Disease stage at initial diagnosis
T stage			0.165
T1/2	11 (13%)	18 (21%)
T3/4	49 (59%)	44 (52%)
TX	23 (28%)	22 (26%)
N stage			0.540
N0	30 (36%)	32 (38%)
N1	25 (30%)	21 (25%)
NX	28 (34%)	31 (37%)
M stage			0.698
M0	35 (42%)	30 (36%)
M1	18 (22%)	13 (15%)
MX	30 (36%)	41 (49%)

↵* Data available for 83 patients in the T-naïve group.
↵† Data available for 82 patients in the T-pretreated group.
NA = not applicable; eGFR = estimated glomerular filtration rate; AST = aspartate aminotransferase; ALT = alanine aminotransferase; GGT = γ-glutamyl transferase.