First mAb administration | Second mAb administration | ||||
Parameter | First time point | Second time point | Third time point | First time point | Second time point |
Patient 1 | |||||
Hours after injection | 2 | 48 | 119 | 49 | 117 |
SUVpeak | |||||
Bone lesion | BLQ | 2.49 | 3.12 | 2.30 | 2.90 |
Bone lesion | 4.19 | 4.55 | 2.60 | 4.80 | 3.51 |
Soft-tissue lesion | 6.47 | 5.42 | 3.14 | 4.59 | 3.53 |
Soft-tissue lesion | 2.26 | 4.53 | 3.60 | 4.87 | 3.10 |
Bone lesion | 4.32 | 5.64 | 3.88 | 6.90 | 5.95 |
Bone lesion | 3.36 | 3.23 | 2.89 | 3.36 | 2.96 |
Patient 2 | |||||
Hours after injection | 2 | 46 | 115 | 44 | 118 |
SUVpeak, lung lesion | 2.22 | 1.87 | 1.57 | 1.71 | 1.57 |
Patient 3 | |||||
Hours after injection | 2 | 50 | 116 | 49 | 139 |
SUVpeak | |||||
Lung lesion | BLQ | 2.19 | 1.26 | 3.59 | 3.78 |
Bone lesion | BLQ | 3.92 | 4.83 | 2.85 | 3.13 |
Bone lesion | BLQ | 5.30 | 5.87 | 5.78 | 6.20 |
Bone lesion | BLQ | 5.45 | 6.12 | 5.49 | 4.87 |
Patient 4 | |||||
Hours after injection | 2 | 51 | 116 | 45 | 115 |
SUVpeak, soft-tissue lesion | NA | 9.94 | 12.01 | 5.72 | 5.92 |
Patient 5 | |||||
Hours after injection | 2 | 42 | 138 | 40 | 113 |
SUVpeak | |||||
Lymph node lesion | NA | 3.69 | 3.84 | 3.11 | 3.97 |
Bone lesion | 15.66 | 15.26 | 6.58 | 11.23 | |
Lymph node lesion | 4.45 | 4.34 | 3.32 | 3.95 | |
Lymph node lesion | 3.96 | 4.06 | 2.72 | 2.92 | |
Lymph node lesion | 3.22 | 2.64 | 4.22 | 3.41 | |
Lymph node lesion | 4.60 | 5.38 | 4.50 | 5.71 |
BLQ = below limit of quantification; NA = not applicable.