TABLE 1

Radionuclide Probes for Various Reporter Genes Used to Image T Cells In Vivo

Radionuclide probe	Reporter target	Immunogenic	Endogenous expression	References
¹⁸F-FEAU	HSV1tk	Yes	None	26, 33
¹²⁴I-FIAU				33
¹⁸F-FHBG				39
¹⁸F-L-FMAU	hdCK3	No	None	27, 28
¹⁸F-L-FIAU, ¹⁸F-FEAU	hdCKDM		None	33
¹²³I-MIBG	hNET	No	Neurons of sympathetic system and those innervating adrenal medulla, lung and placenta	29, 30, 33
¹²⁴I-MIBG				29, 33
¹⁸F-MFBG				33
^99mTcO₄^-	hNIS	No	Thyroid, stomach, salivary glands	31
¹⁸F-tetrafluoroborate				32
¹²⁴I-NaI				34
¹⁸F-NOTAOCT	hSSTR2	No	Cerebrum, kidneys, gastrointestinal tract	35
⁶⁸Ga-DOTATOC				36

¹²⁴I-FIAU = 5-¹²⁴I-iodo-1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)uracil; ¹⁸F-FHBG = 9-[4-¹⁸F-fluoro-3-(hydroxymethyl)butyl]guanine; ¹⁸F-L-FMAU = 1-(2-deoxy-2-¹⁸F-fluoro-β-l-arabinofuranosyl)-5-methyluracil; ^123/124I-MIBG = meta-[^123/124I]iodobenzylguanidine; ¹⁸F-MFBG = meta-¹⁸F-fluorobenzylguanidine;¹⁸F-NOTAOCT = ¹⁸F-NOTA-octreotide; hdCKDM = human deoxycytidine kinase double mutant; hdCK3 = human deoxycytidine kinase triple mutant; hSSTR2 = human somatostatin receptor 2.