TABLE 3

¹⁸F-FDG Pharmacokinetic Rate-Constants for Primary and Metastatic PPGLs

Rate constant	Hereditary cluster 1 tumors (SDHx, VHL) (n = 7)	Hereditary cluster 2 tumors (RET, NF1) (n = 6)	Sporadic tumors (n = 13)
K₁ (mL⋅g⁻¹⋅min⁻¹)	0.28 (0.10–3.25)	0.44 (0.23–0.65)	0.50 (0.18–1.01)
k₂ (min⁻¹)	0.79 (0.13–2.82)	1.08 (0.54–1.50)	0.99 (0.47–1.49)
k₃ (min⁻¹)	0.084 (0.015–0.170)^*	0.041 (0.015–0.062)	0.025 (0.011–0.059)
V_b (mL⋅mL⁻¹)	0.219 (0.080–0.738)^†	0.105 (0.037–0.128)	0.151 (0.072–0.300)

↵* Significantly higher than sporadic tumor values (P < 0.01, Kruskal–Wallis with post hoc Dunn test).
↵† Significantly higher than hereditary cluster 2 values (P < 0.01, Kruskal–Wallis with post hoc Dunn test).
Data are median followed by range in parentheses.