Tumor, Kidney, and Stomach Uptake of 3 Investigated Radiotracers Without or With Phosphoramidon or Thiorphan in Nude Mice Bearing A431-CCK2R(+) and MZ-CRC-1 Xenografts
| Radiotracer | Control | + Phosphoramidon | P | + Thiorphan | P |
| 177Lu-DOTA-MG11 | |||||
| A431-CCK2R(+) | 1.45 ± 0.30 | 7.34 ± 1.64 | <0.0001 | 5.38 ± 1.36 | <0.0001 |
| MZ-CRC-1 | 3.17 ± 1.47 | 17.24 ± 4.81 | <0.0001 | 12.41 ± 4.20 | 0.0007 |
| Kidneys | 1.08 ± 0.15 | 1.36 ± 0.24 | 0.0056 | 1.33 ± 0.41 | 0.1465 |
| Stomach | 1.06 ± 0.23 | 4.04 ± 0.74 | <0.0001 | 3.05 ± 0.83 | <0.0001 |
| 177Lu-DOTA-PP-F11 | |||||
| A431-CCK2R(+) | 6.70 ± 0.56 | 9.34 ± 1.11 | 0.0014 | 8.68 ± 1.18 | 0.0096 |
| MZ-CRC-1 | 11.16 ± 2.94 | 19.72 ± 4.68 | 0.0085 | 8.09 ± 2.17 | 0.1905* |
| Kidneys | 4.30 ± 0.56 | 5.50 ± 0.77 | 0.0008 | 6.56 ± 0.86 | <0.0001* |
| Stomach | 2.18 ± 0.95 | 1.72 ± 0.22 | 0.3227 | 2.20 ± 0.39 | 0.9628 |
| 177Lu-DOTA-PP-F11N | |||||
| A431-CCK2R(+) | 6.94 ± 0.82 | 8.53 ± 2.22 | 0.0855 | 10.01 ± 2.78 | 0.0114 |
| MZ-CRC-1 | 20.68 ± 1.71 | 15.56 ± 3.80 | 0.0215 | 21.82 ± 4.17 | 0.5868 |
| Kidneys | 5.75 ± 1.56 | 5.21 ± 0.78 | 0.1346 | 6.29 ± 1.51 | 0.0002* |
| Stomach | 2.15 ± 0.83 | 2.15 ± 0.55 | 0.9979 | 2.68 ± 0.80 | 0.1511 |
↵* Calculated using Mann–Whitney. P values are with reference to control group of each radiotracer.
Data are mean %IA/g ± SD (n = 5–6) 4 h after injection.