TABLE 3

Biodistribution Results of 177Lu-DOTA-PP-F11N Without and With Phosphoramidon and Thiorphan in Nude Mice Bearing A431-CCK2R(+) and MZ-CRC-1 Xenografts

Organ177Lu-DOTA-PP-F11N177Lu-DOTA-PP-F11N + phosphoramidon177Lu-DOTA-PP-F11N + thiorphan
Blood0.02 ± 0.000.01 ± 0.000.01 ± 0.00
Heart0.02 ± 0.010.02 ± 0.010.02 ± 0.02
Lung0.04 ± 0.020.05 ± 0.020.03 ± 0.02
Liver0.12 ± 0.020.07 ± 0.010.19 ± 0.09
Pancreas0.07 ± 0.030.07 ± 0.020.06 ± 0.03
Spleen0.05 ± 0.030.02 ± 0.010.08 ± 0.03
Stomach2.15 ± 0.832.15 ± 0.552.68 ± 0.80
Intestine0.10 ± 0.080.09 ± 0.050.09 ± 0.06
Kidney5.75 ± 1.565.21 ± 0.786.29 ± 1.51
Muscle0.04 ± 0.030.03 ± 0.020.03 ± 0.02
Bone0.22 ± 0.170.29 ± 0.140.45 ± 0.35
A431-CCK2R(+)6.94 ± 0.828.53 ± 2.2210.01 ± 2.78
MZ-CRC-120.68 ± 1.7115.56 ± 3.8021.82 ± 4.17
  • Data are mean %IA/g ± SD (n = 5–6) 4 h after injection.