TABLE 2

Ex Vivo Biodistribution 3, 24, and 48 Hours After Intravenous Injection of 2 μg of 89Zr-DFO-ZEGFR:03115 Coinjected with 10 μg of Nonlabeled ZEGFR:03115 in Mice Bearing CAL27 Xenografts

Organ3 h24 h48 h
Blood3.70 ± 0.550.87 ± 0.320.23 ± 0.06
Heart0.99 ± 0.190.37 ± 0.120.31 ± 0.04
Lungs2.74 ± 0.930.88 ± 0.130.70 ± 0.08
Kidney130.42 ± 22.25108.80 ± 19.60104.85 ± 11.10
Spleen1.14 ± 0.180.72 ± 0.200.79 ± 0.37
Liver4.99 ± 0.854.31 ± 1.004.11 ± 1.41
Pancreas0.67 ± 0.140.36 ± 0.100.35 ± 0.25
Tumor3.88 ± 0.462.43 ± 0.272.13 ± 0.12
Bone0.99 ± 0.282.28 ± 0.273.44 ± 0.59
Intestine1.09 ± 0.160.42 ± 0.030.40 ± 0.02
Muscle0.38 ± 0.090.14 ± 0.040.16 ± 0.07
Ratio
 Tumor-to-blood1.042.799.34
 Tumor-to-muscle10.3117.3513.56
 Tumor-to-liver0.780.560.52
  • Data are mean ± SD (n ≥ 3) %ID/g.