Radionuclides Used for PRRT in Patients
Isotope | Main decay mode | Half-life | Therapeutic particle and energy | Tissue penetration depth | Status |
177Lu | β−, γ | 6.7 d | β−, E(mean) = 0.149 MeV, E(max) = 0.497 MeV | Mean, 0.5 mm; maximum, 2 mm | MA |
90Y | β− | 2.7 d | β−, E(mean) = 0.937 MeV, E(max) = 2.284 MeV | Mean, 2.5 mm; maximum, 11 mm | MA |
111In | EC | 2.8 d | Auger e−, 0.13–25.6 keV | 0.25 nm–13.6 μm | MA |
213Bi | α | 45.6 min | α, 5.9/8.4 MeV | 85 μm | CS |
225Ac | α | 9.9 d | α, 5.8–8.4 MeV | 47–85 μm | CS |
212Pb | α, β−, EC | 10.6 h | α, 6.2–8.9 Mev | 50–100 μm | CS |
EC = electron capture; MA = marketing authorization; CS = clinical studies.