Parameter | Radiotherapy | Metformin + radiotherapy | Control | P |
Tumor volume (mm3) | 395 ± 57 | 297 ± 51 | 329 ± 65 | 0.5 |
Animal weight (g) | 29.6 ± 0.8 | 29.7 ± 0.9 | 29.4 ± 1.1 | 1.0 |
Baseline 18F-flortanidazole TBR | 3.60 ± 0.17 | 2.74 ± 0.26 | 3.47 ± 0.20 | 0.3 |
Δ18F-flortanidazole TBR (%) | −13 ± 4 | −4 ± 4 | −14 ± 3 | 0.2 |
Δ18F-flortanidazole TBR = change in 18F-flortanidazole TBR after metformin.
Data are expressed as mean ± SEM.