Patient Characteristics
| Patients with centrally reviewed 18F-FDG PET at baseline | ||||
| Characteristic | Measured (n= 310) | Not measurable (n = 119) | Total (n = 429) | Patients without 18F-FDG PET at baseline (n = 1,545) |
| Mean age at HL diagnosis (y) | 34 ± 11 (range, 18–60) | 34 ± 12 (range, 18–59) | 34 ± 11 (range, 18–60) | 34 ± 12 (range, 18–60) |
| Ann Arbor stage IV | 126 (41%) | 42 (35%) | 168 (39%) | 547 (35%) |
| Large mediastinal mass* | 92 (30%) | 41 (35%) | 133 (31%) | 439 (28%) |
| Extranodal involvement | 64 (21%) | 32 (27%) | 96 (22%) | 309 (20%) |
| High ESR† | 269 (87%) | 107 (90%) | 376 (88%) | 1,325 (86%) |
| ≥3 lymph nodes | 165 (54%) | 69 (58%) | 234 (55%) | 1,020 (66%) |
| B symptoms | 176/308 (57%) | 70/118 (59%) | 246/426 (58%) | 1,006/1,542 (65%) |
| IPS | ||||
| 0–1 | 107/306 (35%) | 39/118 (33%) | 146/424 (34%) | 460/1,527 (30%) |
| 2–3 | 157/306 (51%) | 64/118 (54%) | 221/424 (52%) | 817/1,527 (54%) |
| 4–7 | 42/306 (14%) | 15/118 (13%) | 57/424 (13%) | 250/1,527 (16%) |
| PET-2, 18F-FDG uptake‡ | ||||
| DS1 | 103 (33%) | 48 (40%) | 151 (35%) | 532 (34%) |
| DS2 | 46 (15%) | 21 (18%) | 67 (16%) | 262 (17%) |
| DS3 | 79 (26%) | 23 (19%) | 102 (24%) | 379 (25%) |
| DS4 | 81 (26%) | 27 (23%) | 108 (25%) | 372 (24%) |
↵* at least one third of maximal thoracic diameter as measured on chest radiography.
↵† ≥50 mm/h without B symptoms or ≥30 mm/h with B symptoms.
↵‡ Analysis set contained no patient with Deauville score of 5 (17).
HL = Hodgkin lymphoma; ESR = erythrocyte sedimentation rate; IPS = International Prognostic Score; DS = Deauville score.
Data are n followed by percentage in parentheses, except for age.