TABLE 2

Predicted Therapeutic and Posttherapeutic Quantities Based on Pretherapy PET/CT

								V_TU,Tumor (mL)
	RD (%)			D predicted^* (Gy)		BED predicted^* (Gy_α/β)		Therapy predicted^*		Posttherapy predicted^*		Reduction predicted^* (%)
Patient	T1	T2	α_TU (Gy⁻¹), T1, T2	T1	T2	T1	T2	T1	T2	T1	T2	T1	T2
P1	−17	57	0.0176 ± 0.0091	28	17	48	24	11	22	6.4	19	41	11
P2	34	−17	0.0174 ± 0.0091	24	24	36	36	2.3	4.7	1.6	3.2	31	31
P3	−18	−43	0.0161 ± 0.0080	13	13	17	16	15	57	15	59	−0.95	−2.4
P4	−4.7	10	0.0152 ± 0.0066	15	16	21	23	16	36	15	32	7.9	11
P5	120	13	0.0186 ± 0.0080	19	17	27	24	30	20	27	18	10	6.3
P6	30	23	0.0172 ± 0.0090	6.6	6.2	7.7	7.1	85	97	103	118	−21	−21
P7	—	—	—	—	—	—	—	—	—	—	—	—	—
P8	49	28	0.0165 ± 0.0086	21	20	31	30	6.3	21	4.9	17	22	19
P9	−26	−15	0.0187 ± 0.0076	13	11	17	14	24	14	24	14	1.8	−3.2
P10	−23	−15	0.0182 ± 0.0086	17	16	25	21	2.2	6.0	1.9	5.5	14	8.3
P11	3.0	−32	0.0182 ± 0.0086	17	17	25	23	0.38	1.4	0.34	1.1	11	16
P12	−3.9	−12	0.0174 ± 0.0090	15	15	21	21	12	10	11	10	5.6	6.1
P13	−58	−66	0.0163 ± 0.0083	24	39	36	74	6.8	2.2	4.3	0.72	36	68
Mean	1		0.0172	17.7		26		21		21		13
SD	40		0.0084	6.9		14		25		30		19

↵* Predicted = these values were determined (for the beginning of therapy and 6 wk after therapy) using the pretherapeutic PET/CT/and the PBPK/PD model.
RD = relative deviation of predicted and measured tumor volumes 6 wk after therapy; α_TU = radiosensitivities estimated using populations fits and Jackknife method for PSA-positive patients; D = absorbed dose; V_TU,Tumor = tumor volume; Reduction = predicted reduction for 6 wk after therapy relative to the beginning of therapy; T1 and T2 = tumor 1 and tumor 2.