Kinetic Parameters and Total Distribution Volume (VT) Values Estimated with 2TCM, Along with VT Values Estimated Using 1TCM and Logan Analysis for 18F-XTRA PET Imaging in Humans (n = 17)
| 2TCM | ||||||
| ROI | K1 (mL cm−3 min−1) | k2 (min −1) | k3/k4 (unitless) | VT (mL cm−3) | 1TCM, VT (mL cm−3) | Logan, VT (mL cm−3) |
| Thalamus* | 0.61 ± 0.10 (2.9 ± 1.6) | 0.15 ± 0.11 (22.2 ± 12.0) | 13.0 ± 8.1 (21.8 ± 11.2) | 66.6 ± 17.4 (5.4 ± 9.7) | 57.7 ± 13.4 (3.5 ± 1.1) | 64.1 ± 18.4 (2.6 ± 1.0) |
| Striatum | 0.52 ± 0.09 (1.8 ± 1.0) | 0.07 ± 0.02 (9.6 ± 5.9) | 1.29 ± 0.50 (13.6 ± 7.9) | 17.3 ± 3.4 (4.6 ± 4.0) | 14.5 ± 1.9 (2.6 ± 0.5) | 16.7 ± 2.9 (1.1 ± 0.6) |
| Hippocampus | 0.48 ± 0.07 (2.5 ± 1.3) | 0.12 ± 0.05 (11.8 ± 5.9) | 2.92 ± 1.22 (12.1 ± 5.9) | 15.6 ± 1.9 (3.6 ± 2.6) | 12.9 ± 1.5 (3.8 ± 0.6) | 15.6 ± 2.0 (1.8 ± 0.5) |
| Cerebellar cortex | 0.52 ± 0.07 (1.6 ± 0.9) | 0.08 ± 0.03 (10.4 ± 5.2) | 1.80 ± 0.53 (13.3 ± 6.5) | 17.6 ± 3.0 (2.3 ± 2.9) | 15.8 ± 2.3 (2.4 ± 0.5) | 17.7 ± 3.1 (0.6 ± 0.3) |
| Temporal cortex | 0.49 ± 0.08 (1.8 ± 1.3) | 0.10 ± 0.05 (10.1 ± 7.6) | 1.66 ± 1.01 (12.6 ± 8.1) | 13.7 ± 2.2 (2.4 ± 2.5) | 12.2 ± 1.9 (2.6 ± 0.5) | 13.6 ± 2.3 (0.7 ± 0.3) |
| Occipital cortex | 0.56 ± 0.08 (1.7 ± 1.3) | 0.11 ± 0.04 (7.7 ± 6.0) | 1.60 ± 0.80 (9.4 ± 6.4) | 13.4 ± 2.1 (2.5 ± 2.3) | 11.5 ± 1.9 3.2 ± 0.6) | 13.2 ± 2.3 (0.7 ± 0.3) |
| Cingulate cortex | 0.59 ± 0.09 (2.5 ± 1.6) | 0.13 ± 0.08 (12.5 ± 7.8) | 2.35 ± 1.56 (13.9 ± 7.1) | 15.7 ± 2.9 (2.4 ± 2.3) | 14.0 ± 2.4 (3.0 ± 0.5) | 15.8 ± 3.1 (0.7 ± 0.3) |
| Frontal cortex | 0.56 ± 0.08 (2.1 ± 1.5) | 0.12 ± 0.07 (10.5 ± 7.9) | 2.30 ± 1.65 (12.0 ± 7.2) | 15.8 ± 3.1 (2.5 ± 2.4) | 13.8 ± 2.5 (2.9 ± 0.5) | 15.6 ± 3.3 (0.8 ± 0.5) |
| Parietal cortex | 0.57 ± 0.09 (1.8 ± 1.2) | 0.11 ± 0.05 (9.1 ± 6.2) | 1.94 ± 1.07 (10.9 ± 6.1) | 15.1 ± 2.7 (2.5 ± 2.4) | 13.1 ± 2.3 (3.1 ± 0.6) | 15.0 ± 3.0 (0.7 ± 0.3) |
| Corpus callosum | 0.30 ± 0.06 (4.1 ± 1.8) | 0.12 ± 0.06 (21.0 ± 8.5) | 3.15 ± 2.12 (23.5 ± 9.9) | 10.1 ± 1.7 (4.7 ± 4.5) | 8.8 ± 1.5 (3.4 ± 0.7) | 9.8 ± 1.6 (3.5 ± 2.0) |
↵* One individual had poor fit for data from thalamus using all models tested, and these outlier data from thalamus of this individual were excluded. Regional VT values were generated using metabolite-corrected arterial input function and 90-min dynamic data.
Data are mean ± SD, with %COV for each estimated parameter in parentheses.