TABLE 2

Radioligand Target Relative Gene Expression with Rankings of 0–100 Gathered from β-Cell Gene Atlas (20)

Gene expression
RadioligandGeneHuman exocrine pancreasHuman pancreatic isletsHuman primary β-cells*
11C-(+)-PHNO, 11C-FLB457, 11C-racloprideDRD2635574*
DRD3*1*4*69*
11C-DASBSLC6A4596954*
11C-AS2471907HSD11B1447548*
11C-UCB-JSV2A167286*

  • ↵* Retrospective analysis for relative gene expression was examined after completion of PET scans to provide insight into differences of pancreas uptake among the 3 D2/D3 receptor radioligands (11C-raclopride, 11C-FLB457, and 11C-(+)-PHNO). DRD2 = dopamine receptor 2; DRD3 = –dopamine receptor 3; SLC6A4 = serotonin transporter; HSD11B1 = 11β-hydroxysteroid dehydrogenase type 1 enzyme inhibitor; SV2A = synaptic vesicle protein 2A.

  • Expression group rankings: none (0–25), low (25–50), moderate (50–75), enriched (75–100).