TABLE 3

Regional V_T in HC and SP

					Genetic effect		Cohort^*age effect
Brain region	Cohort	Mean^*	SE	SP vs. HC	F	P	F	P
GM	HC	1.67	0.15	+15.14%	3.71	0.0669	6.69	0.0163
	SP	1.93	0.20
Frontal lobe	HC	1.97	0.17	+15.33%	3.65	0.0693	7.14	0.0135
	SP	2.07	0.23
WM	HC	1.37	0.09	+6.97%	0.94	0.3425	4.53	0.0431
	SP	1.47	0.12
Cerebellum	HC	1.74	0.14	+11.50%	5.00	0.0353	6.42	0.0179
	SP	1.94	0.19
Brain stem	HC	2.12	0.17	+15.97%	5.28	0.0311	5.97	0.0223
	SP	2.46	0.22
Thalamus	HC	2.26	0.18	+9.84%	3.87	0.0619	8.55	0.0075
	SP	2.48	0.25
Basal ganglia	HC	1.75	0.13	+13.67%	4.79	0.0394	9.22	0.0057
	SP	1.99	0.18
Hippocampus^†	HC	2.17	0.16	+19.63%	4.07	0.0557	8.76	0.0066
	SP	2.59	0.24
Amygdala	HC	2.05	0.18	+17.83%	5.71	0.0258	9.80	0.0046
	SP	2.42	0.24

↵* Adjusted mean, based on linear mixed-model analysis with cohort, genotype, age, and cohort*age as fixed effects and subject number as random effect.
↵† One subject (SP MAB) was left out because the hippocampus was not properly delineated.
Main age effect and main cohort effect were not included in table.