TABLE 2

Biodistribution and Dosimetry of ¹⁷⁷Lu-HP2 Injected 16 Hours After Z_HER2:342-SR-HP1 in BALB/C nu/nu Mice Bearing SKOV-3 Xenografts

	Uptake
Site	0.3 h	1 h	4 h	24 h	48 h	144 h	216 h	Estimated mean absorbed dose (mGy/MBq)
Blood	2.2 ± 0.3	0.28 ± 0.07	0.019 ± 0.003	0.010 ± 0.005	0.008 ± 0.001			4.0
Heart	0.8 ± 0.1	0.12 ± 0.06	0.03 ± 0.01	0.016 ± 0.007	0.02 ± 0.02			5.4
Lung	1.9 ± 0.2	0.41 ± 0.07	0.15 ± 0.01	0.06 ± 0.01	0.05 ± 0.01			14.4
Salivary gland	0.9 ± 0.2	0.2 ± 0.1	0.06 ± 0.02	0.04 ± 0.01	0.03 ± 0.01			9.3
Liver	0.56 ± 0.06	0.20 ± 0.02	0.15 ± 0.04	0.12 ± 0.03	0.11 ± 0.05	0.06 ± 0.03	0.05 ± 0.02	13.3
Spleen	0.59 ± 0.08	0.14 ± 0.03	0.07 ± 0.02	0.08 ± 0.02	0.06 ± 0.01			12.8
Pancreas	0.5 ± 0.2	0.10 ± 0.02	0.024 ± 0.007	0.017 ± 0.008	0.02 ± 0.01			4.0
Stomach	1.1 ± 0.2	0.19 ± 0.03	0.10 ± 0.03	0.05 ± 0.03	0.033 ± 0.006			12.3
Small intestine	0.7 ± 0.1	0.14 ± 0.02	0.05 ± 0.02	0.03 ± 0.02	0.027 ± 0.007			7.0
Large intestine	0.9 ± 0.3	0.18 ± 0.03	0.07 ± 0.03	0.03 ± 0.02	0.05 ± 0.02			10.4
Kidney	12 ± 2	5 ± 1	4 ± 1	3 ± 1	2.3 ± 0.7	0.7 ± 0.2	0.5 ± 0.2	205.6
Kidney cortex^*								267
Tumor	15 ± 3	20 ± 5	17 ± 3	15 ± 2	12 ± 1	3.4 ± 0.6	1.8 ± 0.3	1,075.4
Skin	1.8 ± 0.3	0.3 ± 0.1	0.13 ± 0.03	0.10 ± 0.05	0.08 ± 0.03	0.03 ± 0.01	0.04 ± 0.02
Muscle	0.6 ± 0.1	0.10 ± 0.04	0.03 ± 0.01	0.014 ± 0.003	0.019 ± 0.008
Bone	0.64 ± 0.07	0.13 ± 0.04	0.04 ± 0.01	0.03 ± 0.01	0.03 ± 0.01			6.8
Brain	0.07 ± 0.01	0.01 ± 0.00	0.004 ± 0.002	0.002 ± 0.002	0.002 ± 0.001			0.6