TABLE 4

Univariate and Multivariate Analyses

	Univariate analysis				Multivariate analysis
Predictor	Category	Overall survival	Hazard ratio	P	Hazard ratio	P
Age (y)	<65	7.8 (5.8–11)	0.9 (0.6–1.2)	0.49	NA	NA
	≥65	7.5 (5–9.4)	1		NA
Sex	Female	9.5 (5.3–13.7)	0.9 (0.6–1.3)	0.6	NA	NA
	Male	7.3 (5.8–8.5)	1		NA
Albumin	>3.5 g/dL	11.7–21	0.4 (0.2–0.7)	0.002	0.7 (0.4–1.4)	0.3
	2.8–3.5 g/dL	7.8 (6.4–11.4)	0.7 (0.5–0.9)		0.7 (0.5–1)	0.07
	<2.8 g/dL	4.8 (4–7.7)	1		1
Bilirubin	<2 mg/dL	8 (7.3–11)	0.15 (0.03–0.6)	<0.0001	0.16 (0.07–0.3)	<0.0001
	2–3 mg/dL	5 (2.2–9.7)	0.24 (0.05–1.2)		0.18 (0.07–0.43)	0.0001
	>3 mg/dL	2 (1.2–3)	1		1
Cirrhosis	Absent	6.8 (6.2–8.9)	0.95 (0.6–1.6)	0.86	NA	NA
	Present	7.7 (5–20)	1		NA
Ascites	Absent	8.8 (7.7–12)	0.6 (0.4–0.85)	0.0015	0.6 (0.4–0.9)	0.01
	Present	4.6 (3.5–6.4)	1		1
Baseline tumor size	≤5 cm	13.9 (11–20)	0.5 (0.4–0.75)	0.0007	0.64 (0.42–0.97)	0.037
	>5 cm	6.4 (5–7.8)	1		1
Number of lesions	Solitary	12.6 (7.7–19)	0.6 (0.4–0.78)	0.001	0.62 (0.4–0.98)	0.04
	Multifocal	6.5 (5–7.9)	1		1
Infiltration	Noninfiltrative	12.6 (7.7–14)	0.67 (0.5–0.9)	0.01	1 (0.7–1.5)	0.9
	Infiltrative tumor	6.2 (4.6–7.7)	1		1
Tumor distribution	Unilobar	9.4 (7.7–13.3)	0.6 (0.4–0.8)	0.0015	0.68 (0.46–1)	0.068
	Bilobar	5 (4.5–6.5)	1		1
AFP	<100	11.4 (7.9–13.9)	0.7 (0.5–0.9)	0.05	0.67 (0.5–0.96)	0.03
	≥100	6.5 (5–7.7)	1		1
ECOG	0	8 (6.7–13.8)	0.32 (0.14–0.78)	0.0001	0.44 (0.24–0.8)	0.01
	1	7.7 (5.2–9.5)	0.35 (0.15–0.8)		0.39 (0.22–0.7)	0.001
	2	2.5 (2–4.6)	1		1
PVT extent	Segmental	13.8 (8.5–15.7)	0.54 (0.36–0.8)	0.008	0.8 (0.5–1.3)	0.4
	Lobar	7.7 (5.3–10.4)	0.7 (0.5–1)		0.8 (0.5–1.2)	0.2
	Main	5 (4–7.7)	1		1

NA = not applicable; ECOG = Eastern Cooperative Oncology Group.
Data in parentheses are 95% CI.