TABLE 3

SUVR of Cortical Florbetapir PET Measured by Different Methods

Amyloid SUVR quantification methods
DiagnosisBrain regionMR-basedGenerated MR-basedNormal PET template–basedMultiatlas PET template–basedPET segmentation–based
Normal controlsCortical1.29 ± 0.181.28 ± 0.17*1.04 ± 0.11†1.17 ± 0.17†1.24 ± 0.14†
Frontal1.27 ± 0.181.26 ± 0.18*1.00 ± 0.12†1.12 ± 0.17†1.22 ± 0.14†
Cingulate1.52 ± 0.231.50 ± 0.24*1.24 ± 0.17†1.48 ± 0.25‡1.41 ± 0.20†
Superior parietal1.49 ± 0.231.49 ± 0.25*1.17 ± 0.18†1.45 ± 0.26†1.38 ± 0.20†
Lateral temporal1.30 ± 0.181.32 ± 0.18‡1.07 ± 0.10†1.20 ± 0.17†1.26 ± 0.14†
MCICortical1.34 ± 0.201.32 ± 0.18‡1.05 ± 0.10†1.21 ± 0.18†1.26 ± 0.15†
Frontal1.32 ± 0.201.30 ± 0.17‡1.05 ± 0.10†1.16 ± 0.17†1.23 ± 0.14†
Cingulate1.57 ± 0.261.57 ± 0.25*1.27 ± 0.17†1.57 ± 0.27*1.45 ± 0.22†
Superior parietal1.55 ± 0.271.55 ± 0.27*1.22 ± 0.21†1.53 ± 0.30*1.42 ± 0.23†
Lateral temporal1.35 ± 0.221.35 ± 0.21*1.08 ± 0.11†1.23 ± 0.19†1.28 ± 0.17†
Alzheimer dementiaCortical1.41 ± 0.191.41 ± 0.18*1.08 ± 0.12†1.32 ± 0.16†1.35 ± 0.15†
Frontal1.40 ± 0.201.38 ± 0.18*1.04 ± 0.13†1.29 ± 0.17†1.31 ± 0.15†
Cingulate1.74 ± 0.211.73 ± 0.22*1.37 ± 0.16†1.76 ± 0.22*1.59 ± 0.16†
Superior parietal1.73 ± 0.251.72 ± 0.26*1.35 ± 0.21†1.74 ± 0.27*1.57 ± 0.20†
Lateral temporal1.43 ± 0.181.45 ± 0.18*1.12 ± 0.12†1.34 ± 0.15†1.38 ± 0.15†

  • ↵* No significant difference with the MR-based method.

  • ↵† P < 0.01.

  • ↵‡ P < 0.05.

  • P values are obtained by paired t tests compared with the MR-based method.