TABLE 4

Comparison of 5 Reference Regions Using Cross-Sectional and Longitudinal Data

Measure	Group	Whole cerebellum	Cerebellar GM	Atlas-based WM	Subject-specific WM	PERSI
SUVr, mean ± SD^*	YCN (n = 16)	1.06 ± 0.08	1.10 ± 0.08	0.98 ± 0.06	0.99 ± 0.07	1.01 ± 0.04
	OCN (n = 52)	1.09 ± 0.07	1.12 ± 0.11	1.06 ± 0.07	1.06 ± 0.07	1.01 ± 0.04
ΔSUVr, mean ± SD^†	OCN/Aβ− (n = 47)	0.01 ± 0.03	0.01 ± 0.04	0.01 ± 0.04	0.01 ± 0.04	0.00 ± 0.02
ΔSUVr, range^‡	OCN/Aβ− (n = 47)	−0.05/0.13	−0.09/0.11	−0.09/0.16	−0.09/0.19	−0.06/0.09
Cohen d SUVr^¶	Aβ+ AD & MCI vs. Aβ− CN	6.10	4.57	5.12	5.43	9.45
	Aβ+ AD vs. Aβ− CN	8.14	6.20	7.01	7.68	13.61
	Aβ+ MCI vs. Aβ− CN	4.80	3.53	3.91	3.99	6.79
Cohen d ΔSUVr^§	Aβ+ AD & MCI vs. Aβ− CN	1.65	1.39	1.82	1.47	2.34
	Aβ+ AD vs. Aβ− CN	2.75	2.03	2.51	2.00	3.19
	Aβ+ MCI vs. Aβ− CN	0.99	0.95	1.34	1.11	1.76

↵* Baseline variability of SUVr measured in Aβ− CNs.
↵† Baseline variability of ΔSUVr measured in Aβ− CNs.
↵‡ Range of ΔSUVr in Aβ− older CNs.
↵¶ Cross-sectional effect sizes (Cohen d).
↵§ Longitudinal effect sizes (Cohen d).
YCN = younger CNs; OCN = older CNs; MCI = mild cognitive impairment.