TABLE 1

K1, K2, and VT of Brain 11C-Erlotinib Before and After Elacridar Administration in Cancer Patients (n = 5)

11C-erlotinib before elacridar11C-erlotinib after elacridar
Patient no.K1K2VTK1K2VTVT ratio
10.0120.0300.3950.0110.0360.3120.790
20.0150.0900.1670.0130.0660.1981.186
3***0.0140.0800.179*
40.0100.0600.1600.0170.0760.2211.381
50.120.1000.1280.0140.1230.1160.906
Mean ± SD0.012 ± 0.0020.070 ± 0.0320.213 ± 0.1230.014 ± 0.0020.076 ± 0.0310.205 ± 0.0711.066 ± 0.268
  • * Data were excluded because peak uptake was missed during first scan.

  • Ratio is based on patients evaluable in both scans.