Summary Statistics for Whole-Body and Serum Clearance
| Whole body | Serum | |||||||
| Measurement | t1/2 eff | t1/2 bio | A1 (%/L) | t1/2 α eff | t1/2 α bio | A2 (%/L) | t1/2 β eff | t1/2 β bio |
| Mean | 67.7 | 521 | 12.6 | 12.1 | 15.5 | 17.3 | 59.3 | 201 |
| SD | 2.3 | 145 | 5.3 | 7.8 | 11.5 | 5.0 | 10.3 | 72 |
| Median | 66.9 | 456 | 13.0 | 9.7 | 11.2 | 16.3 | 55.5 | 176 |
| Minimum | 65.2 | 387 | 5.6 | 3.1 | 3.3 | 11.7 | 50.4 | 141 |
| Maximum | 70.8 | 730 | 18.8 | 22.1 | 30.8 | 23.3 | 78.4 | 322 |
eff = effective half-life; bio = biologic half-life; A1 = partition coefficient for fast component of serum clearance; α = half-time for fast component of serum clearance; A2 = partition coefficient for slow component of serum clearance; β = half-time for slow component of serum clearance.
Whole-body clearance was monoexponential. Serum clearance was biexponential and conformed to the following equation: A1exp(−a1t) + A2exp(−a2t). A1 and A2 are partition coefficients, and respective t1/2 values correspond to ln(2)/a. All half-lives are in hours.