TABLE 2

Longitudinal Analysis of Effect of Cocaine Self-Administration on mGluR5 Availability

		Cluster level			Voxel level		Coordinate
Parameter	Threshold (P)	P_Corr	K_E	Decrease (%)	T	P_Corr	x	y	z	Anatomic structure
Baseline > DE1	0.005 (FWE)	0.0001	1,470	37 ± 6	5.95	0.01	3.2	−6.2	6.6	Hippocampus R (DG)
Baseline > DE2	0.005 (FWE)	0.0003	533	20 ± 8	6.90	0.0001	−0.4	−5.4	2.4	Prefrontal cortex (FAC, PLC)
		0.0001	20,986	25 ± 8	6.68	0.0001	2.2	−4.8	5.6	Hippocampus BL, CPU (S, DG)
Baseline > relapse	0.005 (FWE)	0.0001	14,223	19 ± 7	9.50	0.0001	3.8	−6.4	6.8	Hippocampus R (DG)
		0.0003	539	12 ± 7	9.04	0.0001	−0.2	−5.8	2.4	Prefrontal cortex (FAC, PLC)
		0.0001	4,108	14 ± 8	8.35	0.0001	−6.0	−5.2	7.2	Hippocampus L (CA1)
Baseline > W1	0.0005 (Unc)	0.003	2,330	19 ± 6	4.18	0.02	0.6	−1.2	4.4	Hippocampus BL (FoHC)
Baseline > W2	0.0005 (Unc)	0.002	2,866	14 ± 5	4.62	0.004	−0.4	−0.4	2.0	Cingulate cortex (A2)

DE1/2 = drug-exposure week 1/2; W1/2 = withdrawal week 1/2; FWE = familywise error–corrected; Unc = uncorrected; K_E = cluster extent; T = t-score value; DG = dentate gyrus; FAC = frontal association cortex; PLC = prelimbic cortex; S = subiculum; FoHC = fimbriae of hippocampus; A2 = region A2 of cingulate cortex.