TABLE 1

SPM Results for Clusters of Difference in mGluR5 Availability Between Cocaine and Sucrose Group

		Cluster level				Voxel level		Coordinate
Parameter	Threshold (P)	P_Corr	K_E	∆S (%)	∆C (%)	T	P_Corr	x	y	z	Anatomic structure
Baseline > DE2	0.00001 (FWE)	0.0001	1,631	3	−14	7.90	0.0001	2.1	−0.9	5.2	CPU L, NAC L, AI L, OC L
		0.0001	780	−0	−15	7.82	0.0001	−2.3	−0.8	5.0	CPU R, NAC R
		0.0001	397	−3	−16	6.85	0.0001	−5.5	−1.0	6.5	AI L, OC L
		0.0001	439	−2	−15	6.69	0.0001	−5.2	−6.8	6.7	Hippocampus R (CA1, S)
		0.0001	234	0	−13	6.34	0.0001	−5.2	−5.8	7.2	Hippocampus L (CA1, S)
Baseline > W2	0.00001 (FWE)	0.0001	502	0	−15	7.67	0.0001	−2.3	−0.8	5.0	CPU L, NAC L
		0.0001	701	5	−14	7.65	0.0001	2.1	−0.5	4.7	CPU R, NAC R
Baseline > relapse	0.00001 (FWE)	0.0001	2,478	−0	−24	9.67	0.0001	−2.3	−0.8	5.0	CPU L, NAC L, AI L, OC L
		0.0001	2,892	0	−13	9.34	0.0001	2.1	−0.7	5.1	CPU R, NAC R, AI R, OC R
		0.0001	387	−5	−15	6.89	0.0001	5.2	−6.8	6.7	Hippocampus R (CA1, S)
		0.0001	387	−7	−13	6.69	0.0001	−6.0	−6.0	6.0	Hippocampus L (CA1, S, DG)

DE2 = drug-exposure week 2; W2 = withdrawal week 2; FWE = familywise error–corrected; K_E = cluster extent; ∆S = percentage change between respective phases for sucrose group; ∆C = percentage change between respective phases for cocaine group; T = T-score value; CPU = striatum; NAC = nucleus accumbens; AI = agranular insular cortex; OC = orbital cortex; S = subiculum; DG = dentate gyrus.