TABLE 3

Organ, Tumor, and Tumor-to-Background Uptake Ratios: 68Ga-OPS202 PET/CT Versus 68Ga-DOTATOC PET/CT in Matched Lesion Analysis by On-Site Reader

68Ga-OPS202
Uptake parameter68Ga-DOTATOC15 μg50 μg
Normal organ
 Liver6.5 ( 4.8–8.9)3.4 (2.7–3.6); P = 0.00052.7 (2.5–3.1); P = 0.0005
 Pancreas (uncinate process)3.9 (3.2–5.7)2.2 (2.0–3.6); P = 0.00052.2 (2.0–2.5); P = 0.001
 Gastrointestinal tract5.4 (4.8–5.9)3.4 (2.8–3.8); P = 0.0012.9 (2.4–3.2)*; P = 0.0005
 Lung0.7 (0.6–0.9)1.7 (1.1–2.0); P = 0.00051.6 (1.1–1.9); P = 0.0005
Tumor
 Liver lesions11.8 (10.6–14.0)10.9 (9.5–20.7); P = 0.54712.6 ( 9.6–19.9); P = 0.652
 Extrahepatic lesions14.3 (8.1–16.3)11.8 (7.7–14.6); P = 0.64110.2 (6.3–15.1); P = 0.234
 All lesions12.4 (12.0–14.5)12.3 (9.9–16.9); P = 0.88014.4 (9.6–16.3); P = 0.966
Tumor-to-liver ratio1.9 (1.4–2.9)5.3 (2.9–5.7); P = 0.0044.3 (3.4–6.3); P = 0.008

  • Data are median SUVmax for normal-organ uptake and median of mean SUVmax for tumor uptake and tumor-to-liver ratio, all followed by interquartile range in parentheses. Data in this table were acquired as part of extension study and are not part of original study design.

  • P values are for comparisons with 68Ga-DOTATOC. *For comparisons between 15- and 50-μg 68Ga-OPS202, significant difference was found for physiologic uptake in intestine (P = 0.032); trend close to statistical significance was found for liver and pancreas (P = 0.062 and 0.053, respectively); and no significant difference was found for liver lesions, extrahepatic lesions, all lesions, or tumor-to-liver ratio (P = 0.359, 0.156, 0.186, and 0.547, respectively).