TABLE 1

Affinities and Details About Specific Binding and Nonspecific Binding in Autoradiography

ParameterRO6958948RO6931643RO6924963
Affinity (IC50 in nM)18.510.05.5
Gray matter–to–white matter ratio in AD Braak V8511
Specific binding in gray matter (fmol/mg of protein)5,1625,32010,250
  • IC50 = half-maximal inhibitory concentration.