TABLE 2

SPM of Lower mGlu5 Availability in Alcohol-Dependent Subjects vs. Controls

Cluster level		Voxel level		Peak voxel MNI coordinate			Location
K_EXT	P^*	t score	P^*	x	y	z	Anatomic area	Hemisphere	BA
7,210	<0.001	6.45	<0.001	2	−26	53	Precentral gyrus	Right	4
		5.82	0.001	2	48	21	Anterior cingulate gyrus	Right	32
		5.78	0.001	2	27	36	Anterior cingulate gyrus	Right	24
711	0.007	5.46	0.003	54	−54	48	Parietal lobe, inferolateral remainder	Right	40
748	0.001	5.06	0.008	−6	−78	39	Superior parietal gyrus	Left	39
		4.80	0.017	−29	−75	42	Occipital lobe, lateral remainder	Left	7
874	0.006	4.97	0.011	−6	12	2	Caudate nucleus	Left	—
		4.88	0.014	5	14	−3	Caudate nucleus	Right	—
		4.72	0.022	3	−3	2	Thalamus	Right	—
266	0.019	4.90	0.013	50	20	36	Middle frontal gyrus	Right	44
770	0.007	4.88	0.014	−51	−14	2	Superior temporal gyrus, posterior	Left	48
355	0.015	4.86	0.015	24	−66	57	Superior parietal gyrus	Right	7
290	0.018	4.72	0.021	53	2	−2	Superior temporal gyrus, posterior	Right	38

↵* Corrected for familywise error.
MNI = Montreal Neurological Institute; K_EXT = cluster size extent (number of 2 × 2 × 2 mm voxels); BA = Brodmann area.