TABLE 5

Univariate and Multivariate Logistic Regression Analyses for Predictors of Hematologic Toxicity of Grades 2–5

Univariate analysisMultivariate analysis
Baseline variableOdds ratio95% CIPOdds ratio95% CIP
BSI (per 1-unit increase)1.1471.04–1.260.0051.1121.00–1.230.044
Extent of skeletal disease
 6–20 metastases (vs. <6)3.0000.28–32.210.364
 >20 metastases (vs. <6)4.0320.442–36.780.216
 Superscan (vs. <6)20.01.42–282.450.027
Previous chemotherapy* (yes vs. no)0.9670.29–3.150.956
PSA (μg/L) (per 10-unit increase)1.0131.00–1.0230.018
Hemoglobin (mmol/L) (per 1-unit decrease)2.5951.56–4.31<0.0011.8881.012–3.530.043
Leukocytes (109/L) (per 1-unit decrease)1.2991.06–1.590.0131.3721.05–1.790.019
Thrombocytes (109/L) (per 1-unit decrease)1.0030.99–1.010.249
  • * Previous chemotherapy for mCRPC was defined as docetaxel or cabazitaxel.