Frequency and Severity of Hematologic Toxicity*
| Toxicity | Frequency† | Discontinuation of therapy due to toxicity‡ | Recovery from toxicity§ |
| Anemia | |||
| All grades | 83 (94) | ||
| Grade 2 | 32 (36) | 0 | 0 |
| Grade 3 | 12 (14) | 3 (25) | 1 (8) |
| Grade 4 | 1 (1) | 0 | 0 |
| Grade 5 | 0 | 0 | |
| Leukopenia | |||
| All grades | 37 (42) | ||
| Grade 2 | 20 (23) | 2 (10) | 16 (80) |
| Grade 3 | 5 (6) | 4 (80) | 2 (40) |
| Grade 4 | 3 (3) | 2 (67) | 1 (33) |
| Grade 5 | 1 (1) | 1 (100) | |
| Thrombocytopenia | |||
| All grades | 40 (46) | ||
| Grade 2 | 5 (6) | 3 (60) | 0 |
| Grade 3 | 10 (11) | 9 (90) | 0 |
| Grade 4 | 6 (7) | 6 (100) | 0 |
| Grade 5 | 1 (1) | 1 (100) |
↵* Most severe grade of toxicity occurring within 90 d of preceding 223RaCl2 administration was recorded.
↵† Reported as numbers of patients, with percentages in parentheses.
↵‡ Early discontinuation of therapy (<6 cycles) registered as being due to hematologic toxicity. Reported as numbers of patients with toxicity, with percentages in parentheses. Percentages were calculated from total frequency of given grade of toxicity.
↵§ Defined as normalization of hematologic value (to grade 0) within 180 d from nadir. Reported as numbers of patients with toxicity, with percentages in parentheses. Percentages were calculated from total frequency of given grade of toxicity.