Biodistribution at 3 Days After Injection
| Organ | 111In-D2B | 111In-D2B-DAR2-duocarmycin | 111In-D2B-DAR4-duocarmycin | 111In-D2B-DAR2-MMAE | 111In-D2B-DAR4-MMAE |
| Blood | 12.2 ± 1.1 | 11.4 ± 0.9 | 10.3 ± 1.5 | 18.6 ± 4.7 | 8.8 ± 2.2 |
| Muscle | 1.1 ± 0.3 | 1.2 ± 0.1 | 0.9 ± 0.2 | 1.2 ± 0.3 | 0.7 ± 0.3 |
| Tumor | 75.1 ± 8.1 | 87.7 ± 15.4 | 70.7 ± 15.1 | 119.7 ± 37.4 | 62.1 ± 21.1 |
| Lung | 7.1 ± 1.1 | 8.6 ± 2.3 | 7.0 ± 1.2 | 14.3 ± 5.7 | 5.9 ± 1.7 |
| Spleen | 6.5 ± 1.0 | 4.2 ± 0.5 | 4.1 ± 0.4 | 4.9 ± 1.3 | 2.7 ± 0.5 |
| Kidney | 5.0 ± 0.6 | 4.2 ± 0.5 | 4.1 ± 0.4 | 6.5 ± 1.5 | 7.0 ± 1.7 |
| Liver | 4.9 ± 0.5 | 5.0 ± 1.2 | 7.4 ± 2.4 | 4.9 ± 1.3 | 4.8 ± 1.3 |
| Small intestine | 2.6 ± 0.6 | 2.4 ± 0.8 | 2.0 ± 0.5 | 3.7 ± 1.2 | 1.6 ± 0.5 |
| Salivary gland | 3.7 ± 0.4 | 2.9 ± 0.2 | 2.9 ± 0.4 | 4.5 ± 1.0 | 2.7 ± 0.5 |
| Adrenal gland | 4.1 ± 1.3 | 4.0 ± 0.9 | 3.8 ± 0.5 | 6.0 ± 1.8 | 3.1 ± 0.7 |
Data are mean ± SD (n = 5 mice per group).