TABLE 2

Comparison of Tumor-to-Blood and Tumor-to-Muscle Ratios at 1, 6, and 24 Hours After Administration of 64Cu-NOTA-rEgA, 64Cu-DOTA-rEgA, or 64Cu-DTPA-rEgA to H1650 Tumor–Bearing Mice

Ratio64Cu-NOTA-rEgA64Cu-DOTA-rEgA64Cu-DTPA-rEgA
Tumor-to-blood
 1 h3.50 ± 0.503.71 ± 0.952.57 ± 1.26
 6 h5.00 ± 0.774.25 ± 2.126.01 ± 2.57
 24 h4.58 ± 1.195.39 ± 1.114.76 ± 0.91
Tumor-to-muscle
 1 h8.96 ± 2.729.74 ± 1.404.71 ± 1.72
 6 h16.38 ± 1.7913.35 ± 2.3213.95 ± 6.22
 24 h10.55 ± 1.148.90 ± 1.4311.09 ± 3.36