TABLE 1

Biodistribution of ⁶⁴Cu-NOTA-rEgA, ⁶⁴Cu-DOTA-rEgA, and ⁶⁴Cu-DTPA-rEgA in H1650 Tumor–Bearing Nude Mice at 1, 6, and 24 Hours After Injection

	⁶⁴Cu-NOTA-rEgA			⁶⁴Cu-DOTA-rEgA			⁶⁴Cu-DTPA-rEgA
Site	1 h	6 h	24 h	1 h	6 h	24 h	1 h	6 h	24 h
Blood	2.53 ± 0.22	2.98 ± 0.70	2.18 ± 0.05	2.15 ± 0.67	3.99 ± 1.95	2.17 ± 0.23	2.76 ± 1.16	2.24 ± 0.15	2.41 ± 0.28
Heart	5.09 ± 0.47	4.82 ± 0.47	4.53 ± 0.17	5.15 ± 0.37	4.15 ± 1.02	3.85 ± 0.68	5.56 ± 2.20	4.91 ± 0.65	4.05 ± 0.39
Lung	5.32 ± 1.81	6.13 ± 0.70	5.05 ± 0.77	4.60 ± 1.74	5.52 ± 2.72	5.13 ± 0.48	6.18 ± 3.80	7.42 ± 1.14	5.42 ± 1.02
Liver	13.71 ± 1.17	16.68 ± 1.38	16.58 ± 1.97	16.58 ± 0.92	19.45 ± 2.09	18.46 ± 2.65	25.24 ± 1.95	23.86 ± 1.80	22.44 ± 1.83
Spleen	3.60 ± 0.50	4.17 ± 0.17	3.92 ± 0.37	2.88 ± 0.14	4.48 ± 0.78	4.31 ± 0.46	5.67 ± 0.71	4.63 ± 0.74	4.63 ± 0.39
Stomach	2.67 ± 0.67	3.33 ± 1.15	4.01 ± 0.28	2.86 ± 0.84	2.73 ± 1.42	3.06 ± 1.22	7.02 ± 1.40	3.65 ± 2.05	4.16 ± 2.31
Intestine	11.41 ± 0.42	8.24 ± 0.97	5.64 ± 0.40	12.15 ± 1.14	7.63 ± 0.61	6.00 ± 1.56	15.18 ± 2.45	7.55 ± 0.30	6.14 ± 1.07
Kidney	20.33 ± 1.01	15.88 ± 2.36	15.21 ± 2.10	9.61 ± 0.25	10.88 ± 1.96	9.23 ± 0.69	17.41 ± 1.93	12.14 ± 0.13	12.85 ± 0.85
Pancreas	3.39 ± 0.24	3.65 ± 0.27	2.21 ± 0.18	2.68 ± 0.32	3.51 ± 0.95	3.06 ± 0.93	4.86 ± 0.51	3.25 ± 0.54	2.95 ± 0.48
Muscle	1.02 ± 0.17	0.89 ± 0.16	0.94 ± 0.15	0.79 ± 0.13	1.09 ± 0.14	1.30 ± 0.08	1.41 ± 0.28	0.98 ± 0.15	1.06 ± 0.12
Bone	1.04 ± 0.82	2.12 ± 0.58	1.63 ± 0.33	1.63 ± 0.43	1.74 ± 0.52	1.13 ± 0.34	1.58 ± 0.30	1.77 ± 0.46	1.82 ± 0.58
Brain	0.39 ± 0.06	0.51 ± 0.02	0.57 ± 0.04	0.30 ± 0.05	0.51 ± 0.05	0.63 ± 0.08	0.51 ± 0.12	0.52 ± 0.05	0.70 ± 0.05
Skin	4.23 ± 0.94	3.63 ± 0.43	2.38 ± 0.28	4.16 ± 1.76	4.55 ± 1.31	2.38 ± 0.19	4.10 ± 0.92	3.83 ± 0.31	2.77 ± 0.54
Tumor	8.89 ± 1.04	14.47 ± 1.68	9.97 ± 1.51	7.58 ± 0.31	14.33 ± 0.98	11.51 ± 1.35	6.97 ± 1.50	13.28 ± 2.22	11.61 ± 1.36

Data are expressed as %ID/g (n = 9 mice/group).