TABLE 1

Tumor Growth Rate Analysis Using Linear Mixed Effects Model

Slope log volume*
XenograftAnimals (n) per experimentAnimals (n) per groupExcipient131I-CLR1404P†
Rh301470.180.06<0.0001
TC-711470.140.08<0.0003
TC-1061470.260.10<0.0001
CHLA-201260.130.090.0124
NB-16911890.150.09<0.0001
SAOS-21470.110.08<0.0001

  • ↵* Prediction of tumor growth rate (slope of mixed model function, using logarithmic transformation of tumor volumes).

  • ↵† Comparison between predicted tumor growth rates of excipient vs. drug treatment group.