Clinical Studies of Prognostic Value of Quantitative PET Blood Flow Estimates
| Study | Subjects (n) | Population | Follow-up duration (y) | Primary endpoint | Radiotracer | Adjusted covariates | Hazard ratio |
| Herzog et al. (49) | 256 | Suspected myocardial ischemia | 5.4 | MACE | 13N-ammonia | Age, diabetes, smoking, abnormal perfusion (binary) | 1.6 (MFR < 2.0 vs. ≥ 2.0) |
| Tio et al. (94) | 344 | Ischemic heart disease | 7.1 | Cardiac death | 13N-ammonia | Age, sex | 4.1 (per 0.5 MFR) |
| Slart et al. (93) | 119 | PET-driven revascularization | 7.3 | Cardiac death | 13N-ammonia | Age, sex | 23.6 (MFR < 1.34 vs. > 1.67); 8.3 (MFR 1.34–1.67 vs. > 1.67) |
| Murthy et al. (50) | 2,783 | Clinically indicated PET | 1.4 | Cardiac death | 82Rb | Age, sex, hypertension, dyslipidemia, diabetes, family history of premature CAD, tobacco use, history of CAD, body mass index, chest pain, dyspnea, early revascularization, rest LVEF, summed stress score, LVEF reserve | 5.6 (MFR < 1.5 vs. > 2.0); 3.4 (MFR 1.5–2.0 vs. > 2.0) |
| Fukushima et al. (92) | 224 | Clinically indicated PET | 1.0 | MACE | 82Rb | Age, summed stress score (dichotomized > 4) | 2.9 (MFR < 2.11 vs. ≥ 2.11) |
| Ziadi et al. (53) | 677 | Clinically indicated PET | 1.1 | MACE | 82Rb | History of MI, stress LVEF, summed stress score (dichotomized ≥ 4) | 3.3 (MFR < 2.0 vs. > 2.0) |
| Farhad et al. (227) | 318 | Suspected myocardial ischemia | 1.7 | MACE | 82Rb | Summed stress score | 0.41 per mL/min/g stress MBF |
MACE = major adverse cardiac events (cardiac death, nonfatal MI, late revascularization, cardiac hospitalization); LVEF = left ventricular ejection fraction; MI = myocardial infarction.