Clinical Studies of Prognostic Value of Quantitative PET Blood Flow Estimates

StudySubjects (n)PopulationFollow-up duration (y)Primary endpointRadiotracerAdjusted covariatesHazard ratio
Herzog et al. (49)256Suspected myocardial ischemia5.4MACE13N-ammoniaAge, diabetes, smoking, abnormal perfusion (binary)1.6 (MFR < 2.0 vs. ≥ 2.0)
Tio et al. (94)344Ischemic heart disease7.1Cardiac death13N-ammoniaAge, sex4.1 (per 0.5 MFR)
Slart et al. (93)119PET-driven revascularization7.3Cardiac death13N-ammoniaAge, sex23.6 (MFR < 1.34 vs. > 1.67); 8.3 (MFR 1.34–1.67 vs. > 1.67)
Murthy et al. (50)2,783Clinically indicated PET1.4Cardiac death82RbAge, sex, hypertension, dyslipidemia, diabetes, family history of premature CAD, tobacco use, history of CAD, body mass index, chest pain, dyspnea, early revascularization, rest LVEF, summed stress score, LVEF reserve5.6 (MFR < 1.5 vs. > 2.0); 3.4 (MFR 1.5–2.0 vs. > 2.0)
Fukushima et al. (92)224Clinically indicated PET1.0MACE82RbAge, summed stress score (dichotomized > 4)2.9 (MFR < 2.11 vs. ≥ 2.11)
Ziadi et al. (53)677Clinically indicated PET1.1MACE82RbHistory of MI, stress LVEF, summed stress score (dichotomized ≥ 4)3.3 (MFR < 2.0 vs. > 2.0)
Farhad et al. (227)318Suspected myocardial ischemia1.7MACE82RbSummed stress score0.41 per mL/min/g stress MBF
  • MACE = major adverse cardiac events (cardiac death, nonfatal MI, late revascularization, cardiac hospitalization); LVEF = left ventricular ejection fraction; MI = myocardial infarction.