TABLE 2

Biodistribution of Radiolabeled ADAPT6 in BALB/C nu/nu Mice Bearing SKOV-3 Xenografts

Site	¹¹¹In-DOTA-Cys⁵⁹-ADAPT6	¹²⁵I-HPEM-Cys⁵⁹-ADAPT6	¹¹¹In-DOTA-Cys²-ADAPT6	¹²⁵I-HPEM-Cys²-ADAPT6
1 h
Blood	0.35 ± 0.06^*^,^†	1.0 ± 0.1^*^,^§	0.48 ± 0.10^‡^,^¶	0.54 ± 0.14^‡^,^§
Lung	0.46 ± 0.06^*^,^†	1.4 ± 0.2^*^,^§	0.5 ± 0.1^‡^,^¶	0.6 ± 0.1^‡^,^§
Liver	0.21 ± 0.03^†	2.7 ± 0.8	0.26 ± 0.05^¶	2.4 ± 0.7^‡
Spleen	0.14 ± 0.02^*^,^†^,^§	0.7 ± 0.2^*^,^§	0.23 ± 0.06^‡^,^¶	0.45 ± 0.04^‡^,^§
Stomach	0.23 ± 0.03^*^,^†	1.6 ± 0.3	0.25 ± 0.07^‡^,^¶	1.2 ± 0.3^‡
Kidney	272 ± 21^†	10 ± 2^*	258 ± 27^¶	10 ± 3
Tumor	13 ± 2^†	19 ± 3	14 ± 3^¶	16 ± 3
Muscle	0.10 ± 0.02^*^,^†	0.34 ± 0.03^*^,^§	0.10 ± 0.05^‡^,^¶	0.2 ± 0.1^‡^,^§
Bone	0.21 ± 0.05^*^,^†	0.9 ± 0.2^*^,^§	0.22 ± 0.04^‡	0.31 ± 0.08^‡^,^§
4 h
Blood	0.053 ± 0.004^†	0.41 ± 0.06^§	0.04 ± 0.01^¶	0.20 ± 0.05^§
Lung	0.13 ± 0.03^†^,^§	0.39 ± 0.05^§	0.19 ± 0.02^¶	0.17 ± 0.04^§
Liver	0.17 ± 0.02^§	1.6 ± 0.8	0.22 ± 0.01	0.6 ± 0.3
Spleen	0.10 ± 0.00	0.3 ± 0.2	0.12 ± 0.01	0.15 ± 0.03
Stomach	0.10 ± 0.01^†	1.3 ± 0.3	0.09 ± 0.02^¶	0.8 ± 0.4^¶
Kidney	284 ± 21^†	1.7 ± 0.3	241 ± 32^¶	1.7 ± 0.3
Tumor	15 ± 2^†^,^§	22 ± 3^§	10.6 ± 0.5^¶	11.8 ± 0.5^§
Muscle	0.04 ± 0.01^†	0.18 ± 0.08	0.046 ± 0.005	0.09 ± 0.04
Bone	0.07 ± 0.02^†	0.31 ± 0.06^*^,^§	0.07 ± 0.02	0.12 ± 0.06^§

↵* Significant difference between uptake of Cys⁵⁹-ADAPT6 at 1 and 4 h after injection.
↵† Significant difference between uptake of Cys⁵⁹-ADAPT6 labeled with ¹¹¹In and ¹²⁵I at same time point.
↵‡ Significant difference between uptake of Cys²-ADAPT6 at 1 and 4 h after injection.
↵¶ Significant difference between uptake of Cys²-ADAPT6 labeled with ¹¹¹In and ¹²⁵I at same time point.
↵§ Significant difference between uptake of Cys⁵⁹-ADAPT6 and Cys²-ADAPT6 at same time point.
Data are average %ID/g with SD for 4 animals.