Summary of Results
| Parameter | Baseline (n = 10) | Repeat baseline (n = 10) | 50 mm Hg (n = 10) | 55 mm Hg (n = 9) | 60 mm Hg (n = 9) | Repeat 60 mm Hg (n = 8) | Adenosine (n = 10) | P value determined by ANOVA* |
| PETco2 (mm Hg) | 38.9 ± 2.4 | N/A | 49.9 ± 0.1 | 54.8 ± 0.3 | 59.4 ± 1.2 | 59.7 ± 0.5 | N/A | <0.0001 |
| HR (beats/min) | 57 ± 8 | 59 ± 8 | 62 ± 7 | 66 ± 9 | 68 ± 10 | 69 ± 8 | 76 ± 10 | <0.001 |
| f (breaths/min) | 12 ± 4 | N/A | 17 ± 5 | 19 ± 4 | 22 ± 5 | 23 ± 6 | N/A | <0.001 |
| SBP (mm Hg) | 109 ± 13 | 117 ± 13 | 119 ± 15 | 123 ± 11 | 131 ± 12 | 125 ± 8 | 121 ± 13 | <0.001 |
| DBP (mm Hg) | 65 ± 11 | 71 ± 11 | 68 ± 12 | 70 ± 10 | 74 ± 13 | 71 ± 7 | 70 ± 12 | 0.196 |
| RPP (bpm × mm Hg) | 6,135 ± 1,650 | 6,900 ± 1,165 | 7,140 ± 1,495 | 7,487 ± 1,503 | 8,256 ± 1,493 | 7,666 ± 1,240 | 9,123 ± 1,632 | 0.001 |
| MBF (mL/min/g) | 0.45 ± 0.08 | 0.52 ± 0.10 | 0.62 ± 0.20 | 0.76 ± 0.21 | 0.86 ± 0.24 | 0.89 ± 0.24 | 2.00 ± 0.34 | <0.0001 |
| Corrected MBF (mL/min/g) | 0.44 ± 0.045 | 0.47 ± 0.09 | 0.51 ± 0.15 | 0.57 ± 0.08 | 0.59 ± 0.15 | 0.64 ± 0.19 | 1.37 ± 0.31 | <0.0001 |
| MFR | 1.37 ± 0.317 | 1.68 ± 0.33 | 1.97 ± 0.45 | 2.12 ± 0.48 | 4.53 ± 0.70 | <0.0001 |
↵* Three participants for whom data were missing were excluded from repeated-measures ANOVA.
n = number of participants; N/A = not available.
Values (other than P values) are presented as mean ± SD.