Refractory (n = 7) | Responding (n = 9) | |||||
Biomarker | Evaluation | Mean | Median | Mean | Median | P |
Albumin | BL (g/L) | 38 | 38 | 34 | 39 | 0.31 |
Δ3 | 9% | 5% | 8% | 2% | 0.87 | |
LDH | BL (UI/L) | 211 | 208 | 239 | 225 | 0.74 |
Δ3 | −4% | 0% | −12% | −21% | 0.50 | |
Leukocyte | BL (g/L) | 10.5 | 9.6 | 11.07 | 7.7 | 1.00 |
Δ3 | −20% | −14% | −19% | −18% | 0.50 | |
PNN | BL (g/L) | 6.6 | 6.6 | 8.71 | 6.7 | 0.61 |
Δ3 | −19% | −32% | −30% | −28% | 1.00 | |
PNEo | BL (g/L) | 1.19 | 0.5 | 0.22 | 0.1 | 0.15 |
Δ3† | 39% | 0% | 499% | 75% | 0.75 | |
PNBaso | BL (g/L) | 0.17 | 0 | 0.01 | 0 | 0.20 |
Δ3*† | −67% | −100% | −100% | |||
Lymphocytes | BL (G/L) | 1.83 | 1.4 | 1 | 1.1 | 0.17 |
Δ3* | 13% | −2% | 62% | 33% | 0.35 | |
Monocytes | BL (G/L) | 0.81 | 0.7 | 1.1 | 0.6 | 0.92 |
Δ3 | −2% | 0% | 1% | 0% | 0.50 | |
CRP | BL (mg/dL) | 79 | 40 | 132 | 113 | 0.40 |
Δ3*† | 57% | −85% | −55% | −91% | 0.29 | |
Fibrinogen | BL (G/L)* | 6.32 | 6.8 | 5.64 | 5.7 | 0.60 |
Δ3*† | −16% | −29% | −32% | −29% | 0.14 |
*Missing data in refractory group.
†Missing data in response group.
LDH = lactate dehydrogenase; PNN = polynuclear neutrophils; PNEo = polynuclear eosinophils; PNBaso = polynuclear basophils; CRP = C-reactive protein.
Data are distribution of biologic biomarkers in refractory and responding patients at baseline (BL) and change 3 mo after anti-PD1 initiation (Δ3, expressed as a percentage). Wilcoxon test did not show significant mean differences between those 2 groups.