TABLE 5

Comparison of Lugano Criteria and LYRIC

Criteria	Complete response	Partial response	Progressive disease
Lugano	PET/CT score 1, 2, or 3 with or without a residual mass on 5PS OR on CT, target nodes/nodal masses must regress to ≤1.5 cm in LDi.	PET/CT score 4 or 5 with reduced uptake compared with baseline and residual masses of any size. OR On CT ≥50% decrease in SPD of up to 6 target measurable nodes and extranodal sites.	PET/CT score 4 or 5 with an increase in intensity of uptake from baseline or new ¹⁸F-FDG–avid foci consistent with lymphoma at interim or end-of-treatment assessment. OR On CT, an individual node/lesion must be abnormal with: LDi > 1.5 cm and increase by ≥50% from product of the perpendicular diameters nadir and an increase in LDi or SDi from nadir 0.5 cm for lesions ≤ 2 cm and 1.0 cm for lesions > 2 cm.
			In the setting of splenomegaly, the splenic length must increase by >50% of the extent of its prior increase beyond baseline (e.g., a 15-cm spleen must increase to >16 cm). If no prior splenomegaly, must increase by ≥2 cm from baseline. New or recurrent splenomegaly.
			New or clear progression of preexisiting nonmeasured lesions.
			Regrowth of previously resolved lesions
			A new node > 1.5 cm in any axis or a new extranodal site > 1.0 cm in any axis; if <1.0 cm in any axis, its presence must be unequivocal and must be attributable to lymphoma.
			Assessable disease of any size unequivocally attributable to lymphoma.
			AND/OR new or recurrent involvement of the bone marrow.
LYRIC	Same as Lugano	Same as Lugano	As with Lugano with the following exceptions:
			IR1: ≥50% increase in SPD in first 12 wk.
			IR2a: <50% increase in SPD with new lesions.
			IR2b: <50% increase in SPD with ≥50% increase in PPD of a lesion or set of lesions at any time during treatment.
			IR3: Increase in ¹⁸F-FDG uptake without a concomitant increase in lesion size meeting criteria for progressive disease.

IR = immune response; LDi = longest diameter; SDi = short diameter; SPD = sum of the product of the diameters; PPD = product of the perpendicular diameters.
Refinement of Lugano classification lymphoma response criteria in era of immunomodulatory therapy as proposed by Cheson et al. (18).