TABLE 3

Linear Fit of SPECT to PET Regional MBF and Resulting Sensitivity, Specificity, and A_ROC for Detecting Regional PET MFR Less Than 2 with SPECT MFR for Different Correction Approaches

	SPECT MBF vs. PET MBF linear fit			Regional PET MFR < 2 (n = 23/87)
Correction	R	Residual	Rel. Diff.	Threshold	Sensitivity	Specificity	Accuracy	A_ROC
−BB, −AC, −MC	0.639	0.05 ± 0.65^*	−0.05 ± 0.47	1.64	0.65	0.81	0.77	0.800
+MC	0.668	0.00 ± 0.57^*^,^†	−0.08^† ± 0.45^†	1.81	0.74	0.78	0.77	0.831
+AC, −MC	0.742	0.08 ± 0.54^‡	0.00 ± 0.54	2.24	0.74	0.72	0.72	0.770
+MC	0.816	0.08 ± 0.44^†^,^‡	0.00^† ± 0.44^†	2.26	0.78	0.70	0.72	0.780
+BB, −AC, −MC	0.738	0.01 ± 0.49^*	−0.04 ± 0.39	2.06	0.91	0.66	0.72	0.850
+MC	0.780	−0.04^† ± 0.41^*	−0.07^† ± 0.38	1.79	0.78	0.80	0.79	0.866
+AC, −MC	0.769	0.07 ± 0.48^‡	0.01 ± 0.37	1.81	0.70	0.86	0.82	0.825
+MC	0.847	0.05^† ± 0.37^‡	0.01^† ± 0.33	1.85	0.70	0.86	0.82	0.841

↵* +BB vs. –BB for R, A_ROC, P < 0.004.
↵† +AC vs. –AC for R, A_ROC, P < 0.004.
↵‡ +MC vs. –MC for R, A_ROC, P < 0.004.
Threshold chosen to maximize sensitivity × specificity, using mean Renkin–Crone model parameters (Table 1).
Rel. Diff. = (SPECT/PET)/mean.