TABLE 1

Renkin–Crone Model Fitting, for Images With and Without MC, AC, and BB, and Associated Fit of SPECT to PET Global MBF

SPECT MBF vs. PET MBF
Renkin–Crone modelCorrelationDifferenceDifference/mean
CorrectionR2αβRMeanSDMeanSD
−BB, −AC, −MC0.61*0.109 ± 0.0550.731 ± 0.0830.756*,†0.150.61*,†0.050.39*,†
+MC0.65*,‡0.114 ± 0.0490.692 ± 0.0790.796*,†0.100.47*,†0.040.35*,†
+AC, −MC0.63†0.094 ± 0.0310.516 ± 0.0450.760*,†0.110.55†0.020.38†
+MC0.69†,‡0.090 ± 0.0260.496 ± 0.0380.813*,†0.080.44*,†0.020.34†
+BB, −AC, −MC0.71*,†,‡0.158 ± 0.0640.434 ± 0.0540.843*,†,‡0.090.41*,†0.030.32*,†,‡
+MC0.75*,†,‡0.187 ± 0.0550.400 ± 0.0450.885*,†,‡0.060.32*,†,‡0.030.29*,†,‡
+AC, −MC0.65†,‡0.130 ± 0.0390.308 ± 0.0330.789*,†,‡0.090.48†0.020.36†,‡
+MC0.71†,‡0.140 ± 0.0330.282 ± 0.0270.850*,†,‡0.060.37*,†,‡0.020.32†,‡

  • ↵* +BB vs. –BB, P < 0.004.

  • ↵† +MC vs. –MC, P < 0.004.

  • ↵‡ +AC vs. –AC, P < 0.004.

  • SD is mean SD in MBF difference or difference/mean. Renkin–Crone model: extraction fraction = 1-e(-α-β/F), F = plasma flow (+BB) or blood flow (−BB). Uncertainties estimated from cross-validation analysis.