TABLE 1

Gastrointestinal and Pancreatic Neuroendocrine Cell Types and Secretory Products

Cell typeLocalizationProducts
DeltaEntire gastrointestinal tractSomatostatin
EnterochromaffinEntire gastrointestinal tractSerotonin/substance P/guanylin/melatonin
EnterochromaffinlikeGastric fundusHistamine
GastrinGastric antrum and duodenumGastrin
GhrelinEntire gastrointestinal tractGhrelin
IDuodenumCholecystokinin
KDuodenum/jejunumGastric inhibitory peptide
LSmall intestineGLP-1, PYY, NPY
MotilinDuodenumMotilin
NeurotensinSmall intestineNeurotensin
SecretinDuodenumSecretin
Vasoactive intestinal peptideEntire gastrointestinal tractVasoactive intestinal peptide
XGastric fundus and antrumAmylin
BetaPancreasInsulin
AlphaPancreasGlucagon
DeltaPancreasSomatostatin
Pancreatic polypeptidePancreasPancreatic polypeptide
  • GLP-1 = glucagonlike peptide 1; PYY = polypeptide YY (tyrosine, tyrosine); NPY = neuropeptide Y (tyrosine).