Diagnostic Accuracy
| Consensus reading | Optimistic analysis | Pessimistic analysis | |||||||||||||
| Modality | Sens | Spec | PPV | NPV | ACC | Sens | Spec | PPV | NPV | ACC | Sens | Spec | PPV | NPV | ACC |
| pBS | 64.3 | 96.5 | 75.0 | 94.3 | 91.9 | 56.3 | 97.0 | 75.0 | 93.3 | 91.5 | 68.8 | 81.2† | 36.7 | 94.3 | 79.5‡ |
| SPECT/CT | 60.0 | 92.8 | 56.3 | 93.8 | 88.4 | 56.3 | 93.1 | 56.3 | 93.1 | 88.0* | 62.5 | 89.1 | 47.6 | 93.8 | 85.5 |
| PET/CT | 80.0 | 97.9 | 85.7 | 96.9 | 95.5 | 75.0 | 98.0 | 86.7 | 96.1 | 94.9* | 81.3 | 93.1† | 65.0 | 96.9 | 91.5‡ |
| PET/MRI | 85.7 | 94.9 | 75.0 | 97.4 | 93.5 | 85.7 | 94.9 | 75.0 | 97.4 | 93.5 | 85.7 | 94.9 | 75.9 | 97.4 | 93.5 |
Sens = sensitivity; Spec = specificity; NPV = negative predictive value; ACC = accuracy.
PET/CT showed significantly higher overall accuracy than SPECT/CT with optimistic analysis (*P = 0.039). PET/CT showed significantly higher specificity (†P = 0.012) and overall accuracy (‡P = 0.011) than pBS with pessimistic analysis. All other comparisons were nonsignificant (P > 0.05).